Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Medical research increasingly depends on data-driven, large-scale, multicentric cooperation; however, such cooperation remains obstructed by fragmented procedures, heterogeneity in ethics oversight, complex legal frameworks and regulatory divergence. These structural barriers slow progress, increase costs and ultimately limit benefits to patients. Harmonized, efficient processes and coherent legal frameworks that enable effective collaborative research are feasible and urgently needed.
Healthy oceans are essential for the stability of Earth’s climate and weather patterns, biodiversity and freshwater systems. Despite their vastness, waste from human activities has fundamentally changed oceanic physical, chemical and biological characteristics, threatening human health and well-being. Urgent protective action is required, especially eliminating the extraction and burning of fossil fuels.
Osteoporosis in chronic kidney disease (CKD) grade 4–5D constitutes a profound burden and the treatment gap remains unacceptably wide. People with advanced CKD and osteoporosis should receive comprehensive treatment based on available data, and there is an urgent need to expand the evidence base through inclusion in osteoporosis clinical trials.
In this Review, the authors discuss how pathophysiological mechanisms in chronic kidney disease contribute to an increased susceptibility to the negative consequences of high dietary salt intake and how excess salt can contribute to progressive renal function decline and hypertension.
Current gaps in the management of anti-neutrophil cytoplasmic antibody-associated vasculitis include treatment-associated morbidity and mortality risk. Here, the authors examine research findings on biological readouts of disease activity that might offer biomarkers for monitoring disease activity and inform therapeutic interventions.
Here, the authors describe organelle-specific autophagy pathways and explain how renal cells integrate metabolic and stress signals to shape cargo selection and organelle quality control. They also discuss translational challenges in targeting selective autophagy pathways in kidney disease.
Many glomerular diseases have a genetic basis; however, not all identified variants are pathogenic. This Expert Recommendation from the Clinical Genome Resource (ClinGen) Glomerulopathy Gene Curation Expert Panel describes the outcomes of gene curation efforts to evaluate the evidence underlying asserted gene–disease relationships for 56 genes that have putatively been linked to glomerular diseases.
