A salt shaker over a bowl of soup

Salt and chronic kidney disease

  • Jacob Murray
  • Roos F. Marsman
  • Liffert Vogt
Review Article

Current issue

Volume 22 Issue 8
Contents
View all issues
Subscribe

Announcements

  • Connections between brain and kidney

    This Focus issue examines the epidemiological and mechanistic evidence linking CKD with progressive cognitive decline, including the effects of kidney replacement therapy, and considers interventions with potential to improve outcomes for patients and their caregivers.

  • An ageing tree

    This focus issue explores several issues pertinent to kidney health in the ageing world, including the mechanisms underlying ageing processes in the kidney, epidemiological consequences of population ageing, implications for the treatment of CKD and considerations for CKD diagnosis and transplantation.

  • A box of tools

    This article series presents articles that explore the tools and techniques that are improving our understanding of renal development, physiology and disease mechanisms as well as contributing to advances in the screening, diagnosis and management of kidney diseases.

Advertisement

Latest Reviews & Analysis

    • The complexity of the host responses that underlie sepsis-associated acute kidney injury (SA-AKI) complicates patient management and contributes to its high mortality. Here, the authors examine insights into the pathophysiology of SA-AKI gained from the integration of high-resolution spatial transcriptomics with other multi-omics approaches, and consider how these technologies might enable targeted therapeutic interventions.

      • Moritz Uhlig
      • David Schumacher
      • Rafael Kramann
      Review Article

    • This Review describes current understanding of the epigenetic regulation of kidney development. It describes the epigenetic drivers of cell fate decisions made by nephron progenitor cells, the chromatin landscape of accessible regulatory elements that orchestrate these decisions, and the functional consequences for congenital kidney diseases and the programming of adult kidney disease.

      • Samir S. El-Dahr
      • Jordan Kreidberg
      Review Article

    • This Review provides an overview of the pathophysiology of systemic lupus erythematosus as well as drugs that have been developed to target these pathophysiological processes. The authors also synthesize a translational approach aimed at enabling disease modification in lupus nephritis through the integration of glucocorticoids and conventional antiproliferative agents with immunomodulatory drugs.

      • Mieke van Schaik
      • Cees van Kooten
      • Eleni Frangou
      Review Article

    • This Review focuses on the potassium switch signalling pathway and its regulation of urinary sodium excretion according to plasma potassium levels. Welling and colleagues examine how this pathway affects the interplay between potassium intake, salt handling in the kidney and blood pressure, and its implications for dietary interventions for blood pressure control.

      • Paul A. Welling
      • Eric Delpire
      • Robert A. Fenton
      Review Article

    • In this Review, the authors discuss the advantages, limitations and applications of spatial omics technologies in kidney research. They also discuss novel imaging methods that may extend 2D spatial analyses into 3D modelling, and the complementary applicability of deep-learning-based computational pathology.

      • Takahisa Yoshikawa
      • Roman D. Bülow
      • Motoko Yanagita
      Review Article

News & Comment

  • Taiwan carries one of the world’s heaviest kidney disease burdens globally; however, its single-payer universal health-care system has enabled policy-driven transformation of kidney care through population-level screening, multidisciplinary pay-for-performance programmes, data-driven surveillance and digital innovation. These strategies have reduced disease incidence and improved outcomes, and provide a replicable model for health systems elsewhere.

    • I-Wen Wu
    • Mai-Szu Wu
    Comment

  • The carceral system has the impossible task of providing appropriate care for a vulnerable population while limiting taxpayer spending. Although many risk factors for incarceration also increase the risk of chronic kidney disease (CKD), specific CKD screening requirements or treatment accountability are lacking, which compromises patient care.

    • Laura J. Maursetter
    World View

  • The prevalence of kidney disease is increasing in children and young adults, who face a lifetime of chronic disease with considerable morbidity and mortality. However, a critical shortage in the paediatric nephrology workforce and deficiencies in paediatric-to-adult transition care mean that we fail to meet the needs of this vulnerable population. Paediatric and adult nephrologists need to take collaborative action to address this crisis.

    • Michael Rauchman
    • Carmen M. Halabi
    Comment

  • The thymus is essential for T cell development and a decline in thymic health or a thymectomy therefore have profound clinical implications. Loss of thymic function might contribute to the uraemia-associated ageing of the T cell compartment, and new research is needed to clarify potential underlying mechanisms and effects on patient outcomes.

    • Michiel G. H. Betjes
    • Nicolle H. R. Litjens
    Comment

Trending - Altmetric