Agrimol B

Agrimol B
Identifiers
	IUPAC name (2S)-1-[3,5-bis[(3-butanoyl-2,6-dihydroxy-4-methoxy-5-methylphenyl)methyl]-2,4,6-trihydroxyphenyl]-2-methylbutan-1-one;
CAS Number	55576-66-4;
PubChem CID	194000;
ChemSpider	4475783;
CompTox Dashboard (EPA)	80970914;
Chemical and physical data
Formula	C37H46O12
Molar mass	682.763 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCC(=O)C1=C(C(=C(C(=C1O)CC2=C(C(=C(C(=C2O)C(=O)[C@@H](C)CC)O)CC3=C(C(=C(C(=C3O)C)OC)C(=O)CCC)O)O)O)C)OC;
	InChI InChI=1S/C37H46O12/c1-9-12-23(38)25-32(44)19(29(41)17(5)36(25)48-7)14-21-31(43)22(35(47)27(34(21)46)28(40)16(4)11-3)15-20-30(42)18(6)37(49-8)26(33(20)45)24(39)13-10-2/h16,41-47H,9-15H2,1-8H3/t16-/m0/s1; Key:BVLHMPZMQVWDGX-INIZCTEOSA-N;

Agrimol B is a natural product which is found in the plant Agrimonia pilosa, which is used in traditional herbal medicine in various countries in East Asia. It has a complex spectrum of activity, acting as an activator of the SIRT1 protein but an inhibitor of various other enzyme targets. In animal studies it has anti-obesity, anti-parasitic and anti-cancer effects.^[1]^[2]^[3]^[4]^[5]^[6]

References

↑ Wang S, Zhang Q, Zhang Y, Shen C, Wang Z, Wu Q, et al. (August 2016). "Agrimol B suppresses adipogenesis through modulation of SIRT1-PPAR gamma signal pathway". Biochemical and Biophysical Research Communications. 477 (3): 454–460. doi:10.1016/j.bbrc.2016.06.078. PMID 27320865.
↑ Hnit SS, Ding R, Bi L, Xie C, Yao M, De Souza P, et al. (September 2021). "Agrimol B present in Agrimonia pilosa Ledeb impedes cell cycle progression of cancer cells through G₀ state arrest". Biomedicine & Pharmacotherapy. 141 111795. doi:10.1016/j.biopha.2021.111795. PMID 34098217.
↑ Xiang D, Yang W, Fang Z, Mao J, Yan Q, Li L, et al. (2022). "Agrimol B inhibits colon carcinoma progression by blocking mitochondrial function through the PGC-1α/NRF1/TFAM signaling pathway". Frontiers in Oncology. 12 1055126. doi:10.3389/fonc.2022.1055126. PMC 9794846. PMID 36591497.
↑ Tang J, Li L, Chen Z, Liao C, Hu K, Yang Y, et al. (April 2024). "Agrimol B alleviates cisplatin-induced acute kidney injury by activating the Sirt1/Nrf2 signaling pathway in mice". Acta Biochimica et Biophysica Sinica. 56 (4): 551–563. doi:10.3724/abbs.2023285. PMC 11090851. PMID 38404180.
↑ Dong L, Luo L, Wang Z, Lian S, Wang M, Wu X, et al. (August 2024). "Targeted degradation of NDUFS1 by agrimol B promotes mitochondrial ROS accumulation and cytotoxic autophagy arrest in hepatocellular carcinoma". Free Radical Biology & Medicine. 220: 111–124. doi:10.1016/j.freeradbiomed.2024.04.242. PMID 38697493.
↑ Abudouaini H, Zhang X, Dai Y, Meng Y, Lu Q, Ren Q, et al. (September 2024). "Activating the iNOS regulatory pathway by arginine deprivation targets energy metabolism to induce autophagy-dependent apoptosis against spinal echinococcosis". Biochemical Pharmacology. 227 116453. doi:10.1016/j.bcp.2024.116453. PMID 39059773.

[1] Wang S, Zhang Q, Zhang Y, Shen C, Wang Z, Wu Q, et al. (August 2016). "Agrimol B suppresses adipogenesis through modulation of SIRT1-PPAR gamma signal pathway". Biochemical and Biophysical Research Communications. 477 (3): 454–460. doi:10.1016/j.bbrc.2016.06.078. PMID 27320865.

[2] Hnit SS, Ding R, Bi L, Xie C, Yao M, De Souza P, et al. (September 2021). "Agrimol B present in Agrimonia pilosa Ledeb impedes cell cycle progression of cancer cells through G₀ state arrest". Biomedicine & Pharmacotherapy. 141 111795. doi:10.1016/j.biopha.2021.111795. PMID 34098217.

[3] Xiang D, Yang W, Fang Z, Mao J, Yan Q, Li L, et al. (2022). "Agrimol B inhibits colon carcinoma progression by blocking mitochondrial function through the PGC-1α/NRF1/TFAM signaling pathway". Frontiers in Oncology. 12 1055126. doi:10.3389/fonc.2022.1055126. PMC 9794846. PMID 36591497.

[4] Tang J, Li L, Chen Z, Liao C, Hu K, Yang Y, et al. (April 2024). "Agrimol B alleviates cisplatin-induced acute kidney injury by activating the Sirt1/Nrf2 signaling pathway in mice". Acta Biochimica et Biophysica Sinica. 56 (4): 551–563. doi:10.3724/abbs.2023285. PMC 11090851. PMID 38404180.

[5] Dong L, Luo L, Wang Z, Lian S, Wang M, Wu X, et al. (August 2024). "Targeted degradation of NDUFS1 by agrimol B promotes mitochondrial ROS accumulation and cytotoxic autophagy arrest in hepatocellular carcinoma". Free Radical Biology & Medicine. 220: 111–124. doi:10.1016/j.freeradbiomed.2024.04.242. PMID 38697493.

[6] Abudouaini H, Zhang X, Dai Y, Meng Y, Lu Q, Ren Q, et al. (September 2024). "Activating the iNOS regulatory pathway by arginine deprivation targets energy metabolism to induce autophagy-dependent apoptosis against spinal echinococcosis". Biochemical Pharmacology. 227 116453. doi:10.1016/j.bcp.2024.116453. PMID 39059773.

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