Cirrhosis, portal hypertension and hepatocellular carcinoma (HCC) are interconnected but are often addressed separately. This Review outlines the key interactions between portal hypertension and HCC in cirrhosis, and explores the management of these conditions across all stages, proposing an integrated, stage-based management framework.

In this Review, Lenti and colleagues discuss advances in the epidemiology, pathogenesis, clinical management and endoscopic surveillance of autoimmune gastritis. They also outline directions for future research.

Metabolic dysfunction-associated steatotic liver disease (MASLD) involves multifactorial metabolic, inflammatory and oxidative stress-driven pathology. In this Perspective, we highlight the role of cytochrome P450 oxidoreductase (CPR) as a potentially overlooked regulator of pathways shaping MASLD development and progression.

Intestinal circadian clocks are emerging as important regulators of gastrointestinal physiology and homeostasis. Recent advances suggest that desynchronization of circadian clocks in distinct intestinal cell types could contribute to gastrointestinal dysfunction, highlighting new opportunities to understand disease mechanisms and identify future research priorities.