npj Systems Biology and Applications

Decoding cellular population dynamics through mechanistic modelling and statistical data analysis

Nissrin Alachkar
Nicholas Kwasi-Do Ohene Opoku
Kevin Thurley

Review 25 May 2026

Featured

Inferring absolute counts from proportions by constraining multivariate normal distributions

Jeffrey Hage
Devin Koestler
Brock Christensen
ArticleOpen Access13 May 2026
Network hypermotifs in biological systems: structure, dynamics, and functional implications

Moirangthem Sailash Singh
Priyan Bhattacharya
Karthik Raman
ReviewOpen Access15 Apr 2026
KinForm: kinetics-informed feature optimised representation models for enzyme k_cat and K_M prediction

Saleh Alwer
Ronan M. T. Fleming
ArticleOpen Access28 Mar 2026
Dual RAF inhibition outperforms RAF-MEK combinations for suppressing ERK signaling in KRAS mutant cells

Hiroaki Imoto
Nora Rauch
Boris N. Kholodenko
ArticleOpen Access15 Apr 2026

Announcements

Congratulations to Prof. Réka Albert!

We are excited to share that one of our Associate Editors Prof. Réka Albert (Pennsylvania State University) has been elected to the National Academy of Sciences.
Call for papers: Systems neuroscience

This Collection invites contributions from computational and experimental neuroscience researchers developing new and innovative approaches to understand neuronal function, at different time scales ranging from ECog/EEG to fMRI, and spatial scales ranging from cellular to the whole brain.
Call for papers: Systems mechanobiology

This Collection invites submissions on interplay of mechanical and molecular cues using diverse experimental tools and computational and theoretical approaches.

Open for submissions

Browse articles

Computational identification of amyloid-mimicking microbial peptides with predicted MHC-II presentation relevance to Alzheimer’s disease

Weichen Gong
ArticleOpen Access30 Jul 2026
Theta: a multivariate normative statistic applied to amyloid β panel data in familial Alzheimer’s disease

Isaac Llorente-Saguer
Charles Arber
Neil P. Oxtoby
ArticleOpen Access30 Jul 2026
Fibronectin and E-cadherin regulate unique invasive traits of drug-resistant ovarian cancer cells

Shyamili Goutham
Anchita Gopikrishnan
Ramray Bhat
ArticleOpen Access27 Jul 2026
Computer experimentation reveals mechanisms for signaling and coupled transport that trade efficiency for robust growth

Kazuhiro Maeda
Hiroyuki Kurata
Fred C. Boogerd
ArticleOpen Access24 Jul 2026
Model-guided discovery of MTOR-oriented synergistic drug combinations in colorectal cancer

Viviam Solangeli Bermúdez Paiva
Henri Colyn Bwanika
Åsmund Flobak
ArticleOpen Access23 Jul 2026
Spatial modelling of NOTCH signalling predicts tuneable dynamic heterogeneity in endothelia

Francois Chesnais
Jonas Hue
Lorenzo Veschini
ArticleOpen Access23 Jul 2026
Artificial intelligence perceives marginal gains from MHC class I haplotype data in antigen presentation predictions

Fabio Massimo Zanzotto
Michele Mastromattei
Javier Antonio Alfaro
ArticleOpen Access21 Jul 2026
Wrapshap a high dimension feature selection framework to explore biological systems through machine learning explanations

Félix Furger
Miguel Thomas
Paul Monsarrat
ArticleOpen Access21 Jul 2026
Study of wrap mode impact on Pseudomonas aeruginosa motion in the chemotactic field of fungi

Austin Hansen
Alireza Ramezani
Mark Alber
ArticleOpen Access20 Jul 2026

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Science jobs

Faculty Positions (Life Science and Technology)

The School of Life Science and Technology (SLST) invites applications for numerous tenure-track and tenured positions.

Shanghai (CN)

ShanghaiTech University
Assistant Professor in Neuroimmunology at The Salk Institute for Biological Studies

The Salk invites candidates with a Ph.D and/or M.D. degree to apply for an Assistant Professor position in Neuroimmunology.

La Jolla, California

Salk Institute for Biological Studies - CFO Office
Research Software Engineer for Translational Biomedical AI

Research Software Engineer for Translational Biomedical AI at Human Technopole, Milan- Italy.

Milan (IT)

Human Technopole
Tenured/tenure-track professors and outstanding postdoctoral researchers

2026 Excellent Young Scientists Fund (Overseas)

Kunming, Yunnan, China

Institute of Medical Biology Chinese Academy of Medical Sciences (IMBCAMS)
Faculty Positions in Center of Bioelectronic Medicine, School of Life Sciences, Westlake University

SLS invites applications for multiple tenure-track/tenured faculty positions at all academic ranks.

Hangzhou, Zhejiang, China

Westlake University School of Life Science

This journal is a member of and subscribes to the principles of the Committee on Publication Ethics.

Decoding cellular population dynamics through mechanistic modelling and statistical data analysis

Featured

Inferring absolute counts from proportions by constraining multivariate normal distributions

Network hypermotifs in biological systems: structure, dynamics, and functional implications

KinForm: kinetics-informed feature optimised representation models for enzyme k_cat and K_M prediction

Dual RAF inhibition outperforms RAF-MEK combinations for suppressing ERK signaling in KRAS mutant cells

Announcements

Congratulations to Prof. Réka Albert!

Call for papers: Systems neuroscience

Call for papers: Systems mechanobiology

Browse articles

Computational identification of amyloid-mimicking microbial peptides with predicted MHC-II presentation relevance to Alzheimer’s disease

Theta: a multivariate normative statistic applied to amyloid β panel data in familial Alzheimer’s disease

Fibronectin and E-cadherin regulate unique invasive traits of drug-resistant ovarian cancer cells

Computer experimentation reveals mechanisms for signaling and coupled transport that trade efficiency for robust growth

Model-guided discovery of MTOR-oriented synergistic drug combinations in colorectal cancer

Spatial modelling of NOTCH signalling predicts tuneable dynamic heterogeneity in endothelia

Artificial intelligence perceives marginal gains from MHC class I haplotype data in antigen presentation predictions

Wrapshap a high dimension feature selection framework to explore biological systems through machine learning explanations

Study of wrap mode impact on Pseudomonas aeruginosa motion in the chemotactic field of fungi

Trending - Altmetric

Science jobs

Faculty Positions (Life Science and Technology)

Assistant Professor in Neuroimmunology at The Salk Institute for Biological Studies

Research Software Engineer for Translational Biomedical AI

Tenured/tenure-track professors and outstanding postdoctoral researchers

Faculty Positions in Center of Bioelectronic Medicine, School of Life Sciences, Westlake University

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MoCaPS: a machine learning model for stratification of cancer-associated cachexia based on blood biomarkers

Theta: a multivariate normative statistic applied to amyloid β panel data in familial Alzheimer’s disease

Targeting protein protein interactions and their modulators to enable new therapeutic strategies for human diseases

Computer experimentation reveals mechanisms for signaling and coupled transport that trade efficiency for robust growth

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