npj Aging

The cancer Alzheimer’s disease paradox

L. Rebekah Feng

Comment 02 July 2026

Featured

Network-based discovery of regulatory drivers of cognitive decline in alzheimer’s disease

Danish Anwer
Arina A
Annikka Polster
ArticleOpen Access16 Jul 2026
Biological aging increases risk of postoperative morbidity and mortality: an international, multi-cohort study

Joseph R. Scarpa
M. Cary Reid
Jan Krumsiek
ArticleOpen Access04 Jul 2026
Somatic mutations impose an entropic upper bound on human lifespan

Evgeniy Efimov
Vlad Fedotov
Dmitrii Kriukov
ArticleOpen Access25 Jun 2026
Intermittent hypoxia induces reversible epigenetic age acceleration in old mice

Stefano Donega
Ake T. Lu
Luigi Ferrucci
ArticleOpen Access23 Jun 2026

Announcements

Entropy in Aging - Cologne, 31 Aug - 2 Sep 2026

Discover the pioneering intersection of physics and biology at the upcoming "Entropy in Aging" event, which examines how molecular disorder shapes the aging process. This gathering will highlight cutting-edge breakthroughs in systemic degradation, complex systems biology, and innovative interventions aimed at combating cellular entropy.
Systems Aging - Gordon Research Conference

We are pleased to share that npj Aging will be supporting the 2026 Systems Aging GRC, which will be hosted at the Grand Summit Hotel at Sunday River in Maine, USA.
Our Calls for Papers

Check out our open collections here.
• Frailty.

• Sex differences in aging research.

• Cellular-senescence.

• Immuno-senescence.

• Public health and health governance in China.

• Mitochondria at the Heart of Aging: Structure, Function and Failure.

• Gerophysics.

Browse articles

Epigenetics drives oocyte aging: from mechanisms to interventions

Hui Jia
Jiawei Zhou
Yan Wang
ReviewOpen Access01 Aug 2026
Aging of the neural stem cell niche: integration of local and muscle-derived systemic signals in preclinical and translational contexts

Weiyi Jiang
Kenon Chua
Hong-Wen Tang
ReviewOpen Access01 Aug 2026
Mitochondrial aggregates as a novel quality control mechanism and potential relationship to lipofuscinogenesis

Paula Cilleros-Holgado
Alejandra López-Cabrera
José Antonio Sánchez-Alcázar
ReviewOpen Access31 Jul 2026
Exploring the link between body physiology and cognition: the role of the brain and aging

Irina Buianova
Narun Pat
ArticleOpen Access31 Jul 2026
FGF21-dependent and -independent liver transcriptomic adaptations to low-protein feeding during aging

Jose A. Godoy-Lugo
Khristina E. Young
Cristal M. Hill
ArticleOpen Access31 Jul 2026
Early menopause is associated with reduced global brain activity

Xufu Liu
Liying Luo
Xiao Liu
ArticleOpen Access31 Jul 2026
Programmatic adaptive failure in myeloid cells: a hypothesis-generating framework linking frailty to accelerated epigenetic aging

Tian Wang
Ting Wang
Jinghuan Li
ArticleOpen Access30 Jul 2026
Association of potentially inappropriate prescribing with frailty among older adults with multimorbidity in Northwest Ethiopia

Samuel Agegnew Wondm
Tigabu Eskeziya Zerihun
Fasil Bayafers Tamene
ArticleOpen Access29 Jul 2026
The blood proteome predicts the impact of circulating factors on age-related mitochondrial health

Stephanie R. Heimler
Jaclyn Bergstrom
Anthony J. A. Molina
ArticleOpen Access24 Jul 2026

Collections

Mitochondria at the Heart of Aging: Structure, Function and Failure

This collection invites content on mitochondria in the context of aging --from mechanistic studies to disease models and tool development to relevant therapeutic modalities.

Collection 11 Jul 2025

Trending - Altmetric

Science jobs

Fall 2026 Westlake Fellows Program Nominations and Applications Open

Westlake University is seeking outstanding newly minted or imminent PhD graduates

Hangzhou, Zhejiang (CN)

Westlake University
Faculty Positions at SUSTech School of Medicine

SUSTech School of Medicine offers equal opportunities and welcome applicants from the world with all ethnic backgrounds.

Shenzhen, Guangdong, China

Southern University of Science and Technology, School of Medicine
Assistant Professor Tenure Track, PCMM Boston Children's Hospital, Harvard Medical School Immunology

Assistant Professor, Tenure Track, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Dept. of Immunology, Harvard Medical School

Boston, Massachusetts (US)

Boston Children's Hospital - Program in Cellular and Molecular Medicine
Postdoctoral Fellow in Neurodegeneration in P4Health- Center of Excellence

P4Health CoE is seeking an ambitious Postdoctoral Researcher to join studies investigating astrocytic protein quality control in Alzheimer disease.

Wroclaw (PL)

Łukasiewicz PORT
Director – Sealy Center for Structural Biology (SCSB)

The Director of the Sealy Center for Structural Biology (SCSB) will provide strategic and operational leadership for a multidisciplinary research

Galveston, Texas

University of Texas Medical Branch

This journal is a member of and subscribes to the principles of the Committee on Publication Ethics.

The cancer Alzheimer’s disease paradox

Featured

Network-based discovery of regulatory drivers of cognitive decline in alzheimer’s disease

Biological aging increases risk of postoperative morbidity and mortality: an international, multi-cohort study

Somatic mutations impose an entropic upper bound on human lifespan

Intermittent hypoxia induces reversible epigenetic age acceleration in old mice

Announcements

Entropy in Aging - Cologne, 31 Aug - 2 Sep 2026

Systems Aging - Gordon Research Conference

Our Calls for Papers

Browse articles

Epigenetics drives oocyte aging: from mechanisms to interventions

Aging of the neural stem cell niche: integration of local and muscle-derived systemic signals in preclinical and translational contexts

Mitochondrial aggregates as a novel quality control mechanism and potential relationship to lipofuscinogenesis

Exploring the link between body physiology and cognition: the role of the brain and aging

FGF21-dependent and -independent liver transcriptomic adaptations to low-protein feeding during aging

Early menopause is associated with reduced global brain activity

Programmatic adaptive failure in myeloid cells: a hypothesis-generating framework linking frailty to accelerated epigenetic aging

Association of potentially inappropriate prescribing with frailty among older adults with multimorbidity in Northwest Ethiopia

The blood proteome predicts the impact of circulating factors on age-related mitochondrial health

Collections

Mitochondria at the Heart of Aging: Structure, Function and Failure

Trending - Altmetric

Science jobs

Fall 2026 Westlake Fellows Program Nominations and Applications Open

Faculty Positions at SUSTech School of Medicine

Assistant Professor Tenure Track, PCMM Boston Children's Hospital, Harvard Medical School Immunology

Postdoctoral Fellow in Neurodegeneration in P4Health- Center of Excellence

Director – Sealy Center for Structural Biology (SCSB)

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Somatic mutations impose an entropic upper bound on human lifespan

Cost of care for Alzheimer’s disease and related dementias in the United States: 2016 to 2060

Early-life sugar rationing, brain aging, and long-term neurodegenerative and psychiatric health outcomes: a population-based natural experiment study

How does hormesis impact biology, toxicology, and medicine?

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