A large analysis of MRI studies in five psychiatric disorders reveals that maps of brain volume differences in psychiatric illness are rarely reproducible, highlighting the need for alternative approaches to biomarker discovery.

Forgotten memories in Drosophila persist as silent memory traces and can be recovered by reminder cues. Manipulating reminders can create false memories, showing that memory reconstruction flexibly integrates stored information with recent experiences.

Researchers identify mitochondrial plaques, a previously unrecognized and highly acidic mitochondria-based pathological structure in Alzheimer’s disease, and demonstrate that they result from the dual pathological processes of mitochondrial accumulation and impaired clearance.

Thompson, Rollik and colleagues show that, during sleep, the brain replays procedural memories in the striatum independently of the hippocampus. Replay content was shaped by prior reward and error outcomes and predicted next-day motor performance improvements.

Axons require intracellular transport of cargoes between the soma and the terminus. The authors show a related logistical challenge exists at smaller scale with respect to the interaction of process-bearing oligodendrocytes and the axons they myelinate.

A large analysis of MRI studies in five psychiatric disorders reveals that maps of brain volume differences in psychiatric illness are rarely reproducible, highlighting the need for alternative approaches to biomarker discovery.

Forgotten memories in Drosophila persist as silent memory traces and can be recovered by reminder cues. Manipulating reminders can create false memories, showing that memory reconstruction flexibly integrates stored information with recent experiences.

Mice are motivated to seek information of no extrinsic value. Recording neural activity in orbitofrontal cortex reveals a representation of the value of information that is distinct from the value of physiological reward.

In macaques, old memories, relative to new ones, are supported by more stable and interconnected cell assemblies. New-biased and old-biased assemblies reactivate during overnight sleep and can sometimes reactivate together, suggesting a mechanism for balancing new learning with memory linking and durability.

Researchers identify mitochondrial plaques, a previously unrecognized and highly acidic mitochondria-based pathological structure in Alzheimer’s disease, and demonstrate that they result from the dual pathological processes of mitochondrial accumulation and impaired clearance.

The 2026 closure of the Strait of Hormuz exposed a structural dependency that the neuroimaging community has rarely discussed openly.