Blogs
This summer, I had a chance to speak with Yvette Running Horse Collin, a member of the Lakota Nation and a scientist who trained in both the Western science system and the Lakota system. We discussed the challenges in Western and Lakota science collaboration but also the benefits that could potentially be reaped if the communities can better understand how to work together respectfully. Today&rsqu;
I enjoyed this recent paper here in Science, because (like many organic chemists) I've always enjoyed cycloaddition reactions. I honestly don't know when the last time I ran a straight-up Diels-Alder reaction was, though. That's the prototype 4+2 cycloaddition to form six-membered rings, but it doesn't come up very often in the synthesis of drug compounds. 3+2 dipolar ones to form five-membered he
I've been meaning to write about this case - you see this sort of thing once in a while, but overall it's rare that it gets to the point of filing civil action paperwork. AbbVie is accusing the Chinese company Beigene of stealing their intellectual property for a BTK protein degrader molecule. And the lawsuit says that former AbbVie scientist Huaqing Liu was working on their BTK degrader program u
Editor's Blog
This summer, I had a chance to speak with Yvette Running Horse Collin, a member of the Lakota Nation and a scientist who trained in both the Western science system and the Lakota system. We discussed the challenges in Western and Lakota science collaboration but also the benefits that could potentially be reaped if the communities can better understand how to work together respectfully. Today&rsqu;
There is a lot of confusion and excitement surrounding the questions of whether and how artificial intelligence (AI) will transform mental health care. As a pain physician and psychiatrist, I (D.B.) am unsettled by the abstraction “AI,” especially when I think of individual patients and the concrete reasons they seek treatment.
The amorphous concept of “AI” is better suited
The Editorial page for Science is a high-profile and influential space for commentary that serves the global scientific community. We are always striving to publish the views and opinions of those whose voices have not been adequately represented in our pages, so we welcome submissions. We mostly publish pieces that we have commissioned, but we take a close look at everything we receive. Although
There is a reason that pessimistic narratives about the future pervade popular media—humanity is currently facing a number of great perils, many of which have arisen as a result of our own actions and resist simple solutions. So how do we move forward when the challenges that we face are daunting and a clear path remains elusive?
In 2024, Science will present a limited podcast series hosted
At the nexus of art and health are two leading practitioners of music and biomedical research—Renée Fleming and Francis Collins. Both advocate for a better understanding of the connections between music and the brain (see the Editorial). I spoke to them recently about their shared interest in this area, their hopes for the future of this young field of study, and Renée’s
The television show MythBusters inspired a generation of scientists who are now entering the workforce. I had a chance to talk with co-host Adam Savage, now host of the YouTube channel Tested, about what the show taught him about the scientific process and science communication for an Editorial. Here’s the full text of our interview.
Holden Thorp: When I was the chancellor at UNC [the U
Visuals
The 10 May cover of Science is the 10th cover image captured with technology designed or built in part by Michael Ravine, advanced projects manager at Malin Space Science Systems. His newest cover depicts volcanic activity on Jupiter’s moon Io.
NASA/JPL-Caltech/Southwest Research Institute/Malin Space Science Systems/Björn Jónsson
In a Q&A with Science Senior Photo Editor
Science magazine covers win top prizes
“I will remember walking over the dunes and the scorching Sun on my back.” Those are the memories that will stick with photographer Dado Galdieri from his time spent outside of Tefé, Brazil, shooting for “A river in flux,” a news feature in Science’s 16 February issue.
Each year, the graphics team at Science creates hundreds of scientific illustrations, data visualizations, and maps that explain complex scientific research. From immunology to physics, we work with researchers, reporters, and editors to accurately visualize their latest ideas and processes.
In the Pipeline
I enjoyed this recent paper here in Science, because (like many organic chemists) I've always enjoyed cycloaddition reactions. I honestly don't know when the last time I ran a straight-up Diels-Alder reaction was, though. That's the prototype 4+2 cycloaddition to form six-membered rings, but it doesn't come up very often in the synthesis of drug compounds. 3+2 dipolar ones to form five-membered he
I've been meaning to write about this case - you see this sort of thing once in a while, but overall it's rare that it gets to the point of filing civil action paperwork. AbbVie is accusing the Chinese company Beigene of stealing their intellectual property for a BTK protein degrader molecule. And the lawsuit says that former AbbVie scientist Huaqing Liu was working on their BTK degrader program u
Here's a new paper with interesting data on the hits that come out of large computational docking efforts, and in particular, the hits that aren't actually hits. The authors (the Shoichet group from UCSF) have a lot of experience in this sort of work, and they - like others in the field - have noticed that there's more than one type of wrong answer that turns up in virtual screening in addition to
I wish that I shared Alex Tabarrok's optimism here. He says that "AIs with access to vast databases of genes, proteins, networks and so forth will enable new simulations and learning as has already happened with protein folding", and I can see where that might be an attractive prospect. But there are some major problems with it, in my view. I've made some of these arguments sporadically in ot
Well, since I was talking about CAR-T therapies here the other day, I wanted to highlight this new paper in Cell. Unlike that other post, though, this one has nothing to do with oncology but rather with the rapidly expanding field of using these modified T cells for severe autoimmune diseases. Earlier reports showed remarkable results in patients with refractory lupus, and that same team published
There's been some interesting news on the pharmacological-interventions-in-aging area. This new paper reports a trial of metformin in aging male cynomolgous monkeys (13 to 16 years, roughly 40-50 year old by human standards). A treatment group got 20 mg/kg metformin for over three years (roughly ten years of human lifespan) and these were compared to matched control animals of the same age (and to