COVER The drawing evokes the powerful and momentous potential of cell engineering. The ability to alter cellular regulatory circuitry enables researchers to design modified cells to advance basic science and improve therapies. Investigators can now modify various cell types or groups of cells to operate as smart agents that facilitate experimentation or execute diagnostic or therapeutic functions. See the special section beginning on page 846.
Illustration: Jason Lyon
ONLINE COVER Simulation of a hybrid silicon nanoantenna array on a magnetic field. Digital camera sensors use color filters to selectively capture certain color spectrums. Traditional color filters are separate from the photosensitive silicon that makes up the sensor, causing optical cross-talk which limits the minimum possible pixel size. Ho et al. designed a hybrid silicon-aluminum nanoantenna that would allow the filter and sensor to be close enough together to achieve sub-micron pixel dimensions. This design could replace the traditional dye-based filters in ultra-high pixel density camera sensors.
Credit: Ho et al./Science Advances
ONLINE COVER Rejuvenation Potential of TRM Subsets. This month’s cover depicts a “fountain of youth” from which new tissue resident memory T cells (TRM) are emerging after a secondary infectious challenge. Newly formed CD103– TRM (blue) and CD103+ TRM (red) are derived from proliferating, CD103– precursor cells and join the pool of preexisting CD103+ TRM (gray) that lack this restorative capacity. This model for TRM replenishment is supported by new fate-mapping mouse models described in separate papers by von Hoesslin and Kuhlmann et al. and Fung et al. that are discussed in a Focus by Jensen and Farber.
Credit: Ella Maru Studio
ONLINE COVER Bionics replicate biomechanics. Lower-limb prostheses are often heavy, consume a lot of energy, and do not replicate the natural gait. Tran et al. have developed a powered prosthesis for above-knee amputees that possesses knee, ankle, and toe joints to replicate the biomechanics of the leg. The device is lightweight and capable of regenerating energy during walking to extend its battery life. The researchers validated their design with preclinical studies on above-knee amputees showing the ability to ambulate on level ground and on stairs. This month’s cover is a photograph of the prosthesis device: Utah Bionic Leg.
Credit: Christoph Neumann & Sascha Boldt | Ottobock
ONLINE COVER This week, Rinschen et al. report that the lipid kinase VPS34 limits nutrient loss but enables viral entry in proximal tubule cells in the kidney. The image shows the reduced abundance of ACE2 (green), an entry receptor for the SARS-CoV-2 virus, in the renal cortex of a mouse deficient in VPS34 in proximal tubule cells.
Credit: Rinschen et al./Science Signaling
ONLINE COVER Restoring RBM20. This image shows cardiac tissue from mice carrying an R636Q mutation in the gene encoding RNA binding motif protein 20 (RBM20). In this image, precise in vivo adenine base editing (ABE) has restored the localization of RBM20 (green) to the nucleus (blue) and markedly reduced ribonucleoprotein granules outside the nucleus (cardiac troponin T is shown in red). Nishiyama et al. used ABE and prime editing to precisely correct mutations in RBM20, which are common causes of familial dilated cardiomyopathy, in pluripotent stem cells in vitro. In R636Q/R636Q mice, ABE resulted in improved RBM20 localization, cardiac function, and lifespan, suggesting that these precise editing approaches may be able to treat familial dilated cardiomyopathies.
Credit: Nishiyama et al./Science Translational MedicineThe Open Access journal Research, published in association with CAST, publishes innovative, wide-ranging research in life sciences, physical sciences, engineering and applied science.
The Open Access journal Plant Phenomics, published in association with NAU, publishes novel research that advances plant phenotyping and connects phenomics with other research domains.
The Open Access journal BMEF, published in association with SIBET-CAS, is a platform for the multidisciplinary community of biomedical engineering, publishing wide-ranging research in the field.
The Open Access journal BioDesign Research, published in association with NAU, publishes novel research in the interdisciplinary field of biosystems design.
The Open Access journal Advanced Devices & Instrumentation, published in association with BIACD, is a forum to promote breakthroughs and application advances at all levels of electronics and photonics.
The Open Access journal Cyborg and Bionic Systems, published in association with BIT, promotes the knowledge interchange and hybrid system codesign between living beings and robotic systems.
The Open Access journal Energy Material Advances, published in association with BIT, is an interdisciplinary platform for research in multiple fields from cutting-edge material to energy science.
The Open Access journal Space: Science & Technology, published in association with BIT, promotes the exploration and research of interdisciplinary sciences in the space field.
The Journal of Remote Sensing, an Open Access journal published in association with AIR-CAS, promotes the theory, science, and technology of remote sensing, as well as interdisciplinary research within earth and information science.
The Open Access journal Health Data Science, published in association with PKU, aims to advance the horizon of health data science through transdisciplinary learning, communication, and collaboration with health practitioners and policymakers.
The Open Access journal Ultrafast Science, published in association with XIOPM, publishes cutting-edge and emerging topics in ultrafast science with broad interest from scientific communities.
The Open Access journal Ocean-Land-Atmosphere Research (OLAR), published in association with SML-ZHUHAI, publishes technologically innovative research in marine, terrestrial, and atmospheric studies and the interactions among them.
The Open Access journal Intelligent Computing, published in affiliation with Zhejiang Lab, publishes the latest research outcomes and technological breakthroughs in intelligent computing.
