| Jedd Gyorko | 2b | 25.308 | San Diego Padres | San Diego Padres (MLB) | Activated from DL |
| Carlos Quentin | lf | 31.334 | San Diego Padres | San Diego Padres (MLB) | DL-15 Left knee soreness |
| Jason Lane | P | 37.218 | San Diego Padres | San Diego Padres (MLB) | Contract purchased from minors |
| Preston Guilmet | RP | 27.001 | Baltimore Orioles | Baltimore Orioles (MLB) | Recalled from Norfolk (AAA) |
| Jake Marisnick | cf | 23.120 | Miami Marlins | Miami Marlins (MLB) | Recalled from New Orleans (AAA) |
| Andres Torres | cf | 36.183 | - | | Released by Red Sox |
| Nick Evans | 1B | 28.179 | - | | Released by Diamondbacks |
| Jordan Pacheco | c-1B | 28.179 | Arizona Diamondbacks | Arizona Diamondbacks (MLB) | Activated from DL |
| Erik Bedard | SP | 35.144 | Tampa Bay Rays | Tampa Bay Rays (MLB) | Designated for Assignment |
| Joel Peralta | P | 38.127 | Tampa Bay Rays | Tampa Bay Rays (MLB) | Recalled from minor league rehab assignment |
| Joel Peralta | P | 38.127 | Tampa Bay Rays | Tampa Bay Rays (MLB) | Activated from DL |
| Zoilo Almonte | lf | 25.048 | New York Yankees | New York Yankees (MLB) | Recalled from Scranton/Wilkes-Barre (AAA) |
| Jeff Francis | RP | 33.201 | New York Yankees | New York Yankees (MLB) | Designated for Assignment |
| Billy Burns | CF | 24.332 | Oakland Athletics | Oakland Athletics (MLB) | Contract purchased from minors |
| Craig Gentry | lf-cf | 30.242 | Oakland Athletics | Oakland Athletics (MLB) | DL-15 Broken right hand |
| Christian Colon | SS | 25.075 | Kansas City Royals | Kansas City Royals (MLB) | Recalled from Omaha (AAA) |
| Brett Hayes | c | 30.166 | Kansas City Royals | Kansas City Royals (MLB) | Designated for Assignment |
| Erik Kratz | c | 34.043 | Toronto Blue Jays | Toronto Blue Jays (MLB) | Recalled from Buffalo (AAA) |
| TJ McFarland | RP | 25.050 | Baltimore Orioles | Baltimore Orioles (MLB) | Placed on Bereavement |
| Darwin Barney | 2b | 28.262 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Traded from Cubs to Dodgers for PTBNL |
| Erik Kratz | c | 34.043 | Kansas City Royals | Kansas City Royals (MLB) | Traded from Blue Jays with Liam Hendriks to Royals for Danny Valencia |
| Danny Valencia | dh | 29.312 | Toronto Blue Jays | Toronto Blue Jays (MLB) | Traded from Royals to Blue Jays for Erik Kratz and Liam Hendriks |
| Barry Enright | SP | 28.120 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Signed to minor league contract |
| Mark Appel | P | 23.013 | Houston Astros | Corpus Christi (AA) | Assigned to Corpus Christi (AA) |
| Junior Arias | 3B | 22.201 | Cincinnati Reds | Arizona Reds (Rk) | Activated from disabled list |
| Robbie Aviles | P | 22.224 | Cleveland Indians | Lake County (A) | Activated from disabled list |
| Tanner Bailey | P | 24.022 | Detroit Tigers | Lakeland (A+) | Assigned to Lakeland (A+) |
| Christopher Beck | P | 23.327 | Chicago White Sox | Charlotte (AAA) | Assigned to Charlotte (AAA) |
| Austin Bibens-Dirkx | P | 29.090 | Toronto Blue Jays | New Hampshire (AA) | Assigned to New Hampshire (AA) |
| Torsten Boss | IF | 23.213 | Cleveland Indians | Lake County (A) | Activated from disabled list |
| Matt Boyd | P | 23.176 | Toronto Blue Jays | Dunedin (A+) | Assigned to Dunedin (A+) |
| Tyler Clark | P | 25.205 | Detroit Tigers | Lakeland (A+) | Activated from disabled list |
| Brooks Conrad | 1B-3B | 34.194 | San Diego Padres | El Paso (AAA) | Assigned to El Paso (AAA) |
| Barry Enright | SP | 28.120 | Los Angeles Dodgers | Albuquerque (AAA) | Assigned to Albuquerque (AAA) |
| Paul Eshleman | C | 23.328 | Milwaukee Brewers | Wisconsin (A) | Activated from disabled list |
| Scott Firth | P | 23.207 | Colorado Rockies | Asheville (A) | Assigned to Asheville (A) |
| Tyler Gibson | CF | 21.041 | Detroit Tigers | Lakeland (A+) | Assigned to Lakeland (A+) |
| Angel Gomez | RF-LF | 22.198 | Toronto Blue Jays | Gulf Coast Blue Jays (Rk) | Assigned to Gulf Coast Blue Jays (Rk) |
| Kendall Graveman | P | 23.219 | Toronto Blue Jays | New Hampshire (AA) | Assigned to New Hampshire (AA) |
| Juan Herrera | 2B | 21.030 | St. Louis Cardinals | Peoria (A) | Activated from disabled list |
| Nick Hill | P | 29.179 | Seattle Mariners | Arizona Mariners (Rk) | Activated from disabled list |
| Sean Hurley | OF | 22.084 | Toronto Blue Jays | Bluefield (Rk) | Assigned to Bluefield (Rk) |
| Christian Jones | P | 23.182 | San Francisco Giants | Augusta (A) | Activated from disabled list |
| Ryder Jones | 3B | 20.051 | San Francisco Giants | Salem-Keizer (A-) | Assigned to Salem-Keizer (A-) |
| Jason Kanzler | OF | 23.342 | Minnesota Twins | Fort Myers (A+) | Assigned to Fort Myers (A+) |
| Chris Lamb | P | 24.029 | Oakland Athletics | Sacramento (AAA) | Assigned to Sacramento (AAA) |
| Thomas Lee | P | 24.281 | St. Louis Cardinals | Palm Beach (A+) | Activated from disabled list |
| Chris Leroux | RP | 30.105 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Assigned to Scranton/Wilkes-Barre (AAA) |
| Daniel Lockhart | SS-2B | 21.266 | Chicago Cubs | Boise (A-) | Activated from disabled list |
| Ian McKinney | p | 19.252 | St. Louis Cardinals | State College (A-) | Assigned to State College (A-) |
| Adam Moore | c | 30.081 | San Diego Padres | Arizona Padres (Rk) | Assigned to AZL Padres (Rk) for rehab |
| Yomar Morel | P | 20.252 | Chicago Cubs | Boise (A-) | Assigned to Boise (A-) |
| Nick Mutz | P | 24.043 | San Diego Padres | Fort Wayne (A) | Assigned to Fort Wayne (A) |
| Sean Nolin | SP | 24.214 | Toronto Blue Jays | Buffalo (AAA) | Activated from DL |
| Chad Oberacker | LF | 25.195 | Oakland Athletics | Midland (AA) | Activated from disabled list |
| Joseph Ortiz | RP | 23.349 | Texas Rangers | Frisco (AA) | Assigned to Frisco (AA) |
| Cliff Pennington | ss | 30.043 | Arizona Diamondbacks | Arizona Diamondbacks (Rk) | Assigned to AZL Diamondbacks (Rk) for rehab |
| Andrew Potter | P | 20.169 | Arizona Diamondbacks | Arizona Diamondbacks (Rk) | Assigned to Arizona Diamondbacks (Rk) |
| Felix Ramos | P | 20.238 | Miami Marlins | Gulf Coast Marlins (Rk) | Assigned to Gulf Coast Marlins (Rk) |
| Pierce Rankin | C | 25.093 | Toronto Blue Jays | Dunedin (A+) | Activated from disabled list |
| J.T. Realmuto | C | 23.132 | Miami Marlins | Jacksonville (AA) | Assigned to Jacksonville (AA) |
| Hector Roa | 3B | 19.149 | Houston Astros | Greeneville (Rk) | Assigned to Greeneville (Rk) |
| Wilman Rodriguez | OF | 23.051 | Washington Nationals | Hagerstown (A) | Assigned to Hagerstown (A) |
| Chipper Smith | P | 24.187 | Miami Marlins | Gulf Coast Marlins (Rk) | Activated from disabled list |
| Zeke Spruill | SP | 24.320 | Arizona Diamondbacks | Arizona Diamondbacks (Rk) | Activated from disabled list |
| Dylan Stamey | P | 22.203 | Colorado Rockies | Tri-City (A-) | Assigned to Tri-City (A-) |
| Jackson Stephens | P | 20.078 | Cincinnati Reds | Arizona Reds (Rk) | Assigned to Arizona Reds (Rk) |
| Oscar Tejeda | 2B | 24.214 | Washington Nationals | Harrisburg (AA) | Assigned to Harrisburg (AA) |
| Wilfredo Tovar | SS | 22.352 | New York Mets | St. Lucie (A+) | Assigned to St. Lucie (A+) |
| John Wooten | 3B | 23.190 | Washington Nationals | Potomac (A+) | Assigned to Potomac (A+) |
| Liam Hendriks | SP | 25.168 | Kansas City Royals | Omaha (AAA) | Traded from Blue Jays with Erik Kratz to Royals for Danny Valencia |
| Chris Herrmann | c | 26.247 | Minnesota Twins | Rochester (AAA) | DL-7 Injured |
| Kameron Loe | RP | 32.321 | Arizona Diamondbacks | Reno (AAA) | DL-7 Injured |
| Matt Palmer | P | 35.129 | Seattle Mariners | Tacoma (AAA) | DL-7 Injured |
| Max Ramirez | C | 29.290 | | | Released by Royals |
| Mike Nickeas | C | 31.165 | Toronto Blue Jays | Buffalo (AAA) | DL-7 Injured |
| Gabriel Noriega | SS-2B | 23.318 | Seattle Mariners | Tacoma (AAA) | DL-7 Injured |
| Jake Lemmerman | SS | 25.085 | San Diego Padres | El Paso (AAA) | DL-7 Injured |
| Richard Bleier | P | 27.103 | Toronto Blue Jays | New Hampshire (AA) | DL-7 Injured |
| Christopher Manno | P | 25.266 | | | Released by Nationals |
| Sam Gaviglio | P | 24.067 | St. Louis Cardinals | Springfield (AA) | DL-7 Injured |
| Zane Chavez | C | 27.210 | Baltimore Orioles | Bowie (AA) | DL-7 Injured |
| Brady Lail | P | 20.353 | New York Yankees | Tampa (A+) | DL-7 Injured |
| Dreily Guerrero | 2B-3B | 23.289 | Boston Red Sox | Salem (A+) | DL-7 Injured |
| Tyler Spurlin | P | 23.041 | Milwaukee Brewers | Brevard County (A+) | DL-7 Injured |
| Jorge Martinez | SS | 21.121 | | | Released by Indians |
| Dioscar Romero | P | 19.102 | Boston Red Sox | Lowell (A-) | DL-60 Injured |
| Noel De La Cruz | P | 22.224 | Seattle Mariners | Everett (A-) | DL-7 Injured |
| Randy Perez | P | 20.118 | Boston Red Sox | Lowell (A-) | DL-7 Injured |
| Justin Marks | P | 26.198 | - | | Cleared Waivers and Became a Free Agent |
| Kyle Fischer | P | 23.167 | Miami Marlins | Gulf Coast Marlins (Rk) | Assigned to GCL Marlins (Rk) |
| AJ Reed | P | 21.079 | Houston Astros | Quad Cities (A) | Assigned to Quad Cities (A) |
| Chris Sadberry | P | 22.263 | Miami Marlins | Greensboro (A) | Assigned to Greensboro (A) |
| Jeremy Farrell | 3B | 27.259 | Chicago White Sox | Birmingham (AA) | Suspended 5 games for role in bench clearing brawl |
| Brett Ash | P | 23.062 | Seattle Mariners | Everett (A-) | Assigned to Everett (A-) |
| Jeremy Null | P | 20.304 | Chicago Cubs | Arizona Cubs (Rk) | Signed out of draft (Western Carolina) |
| Nicky Delmonico | 1B-2B | 22.016 | Milwaukee Brewers | Brevard County (A+) | Suspended 50 games for violating Minor League drug policy |
| Christian Muscarello | SS | 22.042 | St. Louis Cardinals | Johnson City (Rk) | Signed as undrafted free agent (Trinity) |