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Substance Name: Lithium carbonate [USAN:USP:JAN]
RN: 554-13-2
UNII: 2BMD2GNA4V
InChIKey: XGZVUEUWXADBQD-UHFFFAOYSA-L

Note

  • A lithium salt, classified as a mood-stabilizing agent. Lithium ion alters the metabolism of BIOGENIC MONOAMINES in the CENTRAL NERVOUS SYSTEM, and affects multiple neurotransmission systems.

Molecular Formula

  • C-H2-O3.2Li

Molecular Weight

  • 73.89
 

Classification Codes

  • Antidepressive Agents
  • Antimanic
  • Antimanic Agents
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Human Data
  • Mutation Data
  • Psychotropic Drugs
  • Reproductive Effect
  • Tranquilizing Agents
  • Tumor Data

Names and Synonyms

Name of Substance

  • Lithium carbonate
  • Lithium carbonate [USAN:USP:JAN]

MeSH Heading

  • Lithium carbonate

Synonyms

  • Camcolit
  • Candamide
  • Carbolith
  • Carbolitium
  • Carbonic acid lithium salt
  • Carbonic acid lithium salt (Li2CO3)
  • Carbonic acid, dilithium salt
  • CCRIS 3153
  • Ceglution
  • CP 15467-61
  • CP-15,467-61
  • CP-15467-61
  • Dilithium carbonate
  • EC 209-062-5
  • EINECS 209-062-5
  • Eskalith
  • Eskalith CR
  • Eutimin
  • HSDB 3351
  • Hypnorex
  • Limas
  • Liskonum
  • Litard
  • Lithane
  • Lithea
  • Lithicarb
  • Lithinate
  • Lithionate
  • Lithium carbonate
  • Lithium carbonate (Li2CO3)
  • Lithium carbonicum
  • Lithium Phasal
  • Lithizine
  • Litho-Carb
  • Lithobid
  • Lithonate
  • Lithotabs
  • Liticar
  • Manialith
  • Maniprex
  • Micalith
  • Neurolepsin
  • NSC-16895
  • Pfi-lithium
  • Pfl-Lithium
  • Phasal
  • Plenur
  • Priadel
  • Quilonorm
  • Quilonum retard
  • Teralithe
  • Teralithe [French]
  • UNII-2BMD2GNA4V

Systematic Names

  • Carbonic acid, dilithium salt
  • Carbonic acid, lithium salt (1:2)
  • Lithium carbonate
  • Lithium carbonate (2:1)

Superlist Name

  • Lithium carbonate

Registry Numbers

CAS Registry Number

  • 554-13-2

FDA UNII

  • 2BMD2GNA4V

Other Registry Numbers

  • 12767-19-0
  • 1312765-65-3
  • 216964-61-3

Related Registry Number

  • 10377-37-4 (mono-lithium salt)

System Generated Number

  • 0000554132

Molecular Formulas

Molecular Formula

  • C-H2-O3.2Li

Molecular Formula Fragments

  • C-H2-O3
  • COMPONENT
  • Li

Structure Descriptors

InChI

1S/CH2O3.2Li/c2-1(3)4;;/h(H2,2,3,4);;/q;2*+1/p-2

InChIKey

XGZVUEUWXADBQD-UHFFFAOYSA-L

Smiles

C(=O)([O-])[O-].[Li+].[Li+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 500mg/kg (500mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 436, 1972.
human TDLo oral 4111mg/kg (4111mg/kg) BEHAVIORAL: TREMOR

GASTROINTESTINAL: OTHER CHANGES

BEHAVIORAL: MUSCLE WEAKNESS		 New England Journal of Medicine. Vol. 287, Pg. 867, 1972.
man TDLo oral 8mg/kg (8mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"

GASTROINTESTINAL: NAUSEA OR VOMITING		 American Journal of Psychiatry. Vol. 141, Pg. 909, 1984.
man TDLo oral 54mg/kg (54mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: SLEEP		 New Zealand Medical Journal. Vol. 97, Pg. 23, 1984.
man TDLo oral 1080mg/kg/13W (1080mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE" Journal of Clinical Psychiatry. Vol. 47, Pg. 330, 1986.
man TDLo oral 25gm/kg/4Y-I (25000mg/kg) SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE

BEHAVIORAL: TREMOR		 Journal of Clinical Psychiatry. Vol. 46, Pg. 292, 1985.
mouse LD50 intraperitoneal 236mg/kg (236mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: EXCITEMENT		 Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 1273, 1973.
mouse LD50 intravenous 497mg/kg (497mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)		 Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 1273, 1973.
mouse LD50 oral 531mg/kg (531mg/kg)   Russian Pharmacology and Toxicology Vol. 33, Pg. 266, 1970.
mouse LD50 subcutaneous 413mg/kg (413mg/kg)   Russian Pharmacology and Toxicology Vol. 33, Pg. 266, 1970.
rat LD50 intraperitoneal 156mg/kg (156mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 1273, 1973.
rat LD50 intravenous 241mg/kg (241mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)		 Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 1273, 1973.
rat LD50 oral 525mg/kg (525mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 1273, 1973.
rat LD50 subcutaneous 434mg/kg (434mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE		 Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 1273, 1973.
women TDLo oral 120mg/kg/10D- (120mg/kg) BEHAVIORAL: EXCITEMENT Journal of Clinical Psychiatry. Vol. 48, Pg. 81, 1987.
women TDLo oral 612mg/kg/44D- (612mg/kg) BEHAVIORAL: SLEEP

SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE"		 American Journal of Psychiatry. Vol. 152, Pg. 956, 1995.
women TDLo oral 8760mg/kg/2Y- (8760mg/kg) ENDOCRINE: THYROID WEIGHT (GOITER)

ENDOCRINE: EVIDENCE OF THYROID HYPERFUNCTION 		American Journal of Medicine. Vol. 99, Pg. 575, 1995.
women TDLo oral 36500mg/kg/10 (36500mg/kg) ENDOCRINE: DIABETES INSIPIDUS (NEPHROGENIC OR CNS)

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED		 Annales de Medecine Interne. Vol. 148, Pg. 284, 1997.
women TDLo unreported 556mg/kg/32D (556mg/kg) BEHAVIORAL: TOXIC PSYCHOSIS JAMA, Journal of the American Medical Association. Vol. 213, Pg. 865, 1970.