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KNT-127, a selective delta opioid receptor agonist, shows beneficial effects in the hippocampal dentate gyrus of a chronic vicarious social defeat stress mouse model.

Yoshioka T, Yamada D, Segi-Nishida E, Nagase H, Saitoh A. Yoshioka T, et al. Neuropharmacology. 2023 Jul 1;232:109511. doi: 10.1016/j.neuropharm.2023.109511. Epub 2023 Mar 30. Neuropharmacology. 2023. PMID: 37001727

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A non-convulsant delta-opioid receptor agonist, KNT-127, reduces cortical spreading depression and nitroglycerin-induced allodynia.

Bertels Z, Witkowski WD, Asif S, Siegersma K, van Rijn RM, Pradhan AA. Bertels Z, et al. Headache. 2021 Jan;61(1):170-178. doi: 10.1111/head.14019. Epub 2020 Dec 16. Headache. 2021. PMID: 33326598 Free PMC article.

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Effects of the delta opioid receptor agonist KNT-127 on electroencephalographic activity in mice.

Saitoh A, Tominaga H, Ogawa Y, Irukayama-Tomobe Y, Yamada M, Yanagisawa M, Nagase H. Saitoh A, et al. Pharmacol Rep. 2018 Apr;70(2):350-354. doi: 10.1016/j.pharep.2017.08.018. Epub 2017 Oct 28. Pharmacol Rep. 2018. PMID: 29477045

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Role for μ-opioid receptor in antidepressant effects of δ-opioid receptor agonist KNT-127.

Moriya Y, Kasahara Y, Shimada M, Sakakibara Y, Fujii H, Nagase H, Ide S, Ikeda K, Hall FS, Uhl GR, Sora I. Moriya Y, et al. J Pharmacol Sci. 2023 Mar;151(3):135-141. doi: 10.1016/j.jphs.2022.12.008. Epub 2022 Dec 28. J Pharmacol Sci. 2023. PMID: 36828615 Free article.

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Selective agonists of the δ-opioid receptor, KNT-127 and SNC80, act differentially on extinction learning of contextual fear memory in mice.

Yamada D, Yanagisawa S, Yoshizawa K, Yanagita S, Oka JI, Nagase H, Saitoh A. Yamada D, et al. Neuropharmacology. 2019 Dec 1;160:107792. doi: 10.1016/j.neuropharm.2019.107792. Epub 2019 Sep 22. Neuropharmacology. 2019. PMID: 31553899

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In vivo properties of KNT-127, a novel δ opioid receptor agonist: receptor internalization, antihyperalgesia and antidepressant effects in mice.

Nozaki C, Nagase H, Nemoto T, Matifas A, Kieffer BL, Gaveriaux-Ruff C. Nozaki C, et al. Br J Pharmacol. 2014 Dec;171(23):5376-86. doi: 10.1111/bph.12852. Br J Pharmacol. 2014. PMID: 25048778 Free PMC article.

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The novel δ opioid receptor agonist KNT-127 produces antidepressant-like and antinociceptive effects in mice without producing convulsions.

Saitoh A, Sugiyama A, Nemoto T, Fujii H, Wada K, Oka J, Nagase H, Yamada M. Saitoh A, et al. Behav Brain Res. 2011 Oct 1;223(2):271-9. doi: 10.1016/j.bbr.2011.04.041. Epub 2011 May 5. Behav Brain Res. 2011. PMID: 21565223

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The delta opioid receptor agonist KNT-127 relieves innate anxiety-like behavior in mice by suppressing transmission from the prelimbic cortex to basolateral amygdala.

Kawaminami A, Yamada D, Yoshioka T, Hatakeyama A, Nishida M, Kajino K, Saitoh T, Nagase H, Saitoh A. Kawaminami A, et al. Neuropsychopharmacol Rep. 2024 Mar;44(1):256-261. doi: 10.1002/npr2.12406. Epub 2023 Dec 29. Neuropsychopharmacol Rep. 2024. PMID: 38156409 Free PMC article.

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Novel δ1-receptor agonist KNT-127 increases the release of dopamine and L-glutamate in the striatum, nucleus accumbens and median pre-frontal cortex.

Tanahashi S, Ueda Y, Nakajima A, Yamamura S, Nagase H, Okada M. Tanahashi S, et al. Neuropharmacology. 2012 Apr;62(5-6):2057-67. doi: 10.1016/j.neuropharm.2012.01.005. Epub 2012 Jan 17. Neuropharmacology. 2012. PMID: 22266218

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The delta opioid receptor agonist KNT-127 in the prelimbic medial prefrontal cortex attenuates veratrine-induced anxiety-like behaviors in mice.

Saitoh A, Suzuki S, Soda A, Ohashi M, Yamada M, Oka JI, Nagase H, Yamada M. Saitoh A, et al. Behav Brain Res. 2018 Jan 15;336:77-84. doi: 10.1016/j.bbr.2017.08.041. Epub 2017 Aug 31. Behav Brain Res. 2018. PMID: 28864205

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