The Builders

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Whose imagination do you want to live in? In this new series, bestselling biographer Walter Isaacson sits down with the most consequential names in AI and tech to understand the futures they're racing to build. Elon Musk, Peter Thiel, Alex Karp, Fei-Fei Li, Dario and Daniela Amodei, and more open up about their ambitions, what frightens them, how they think about humanity, and what drives them to build so big and so fast. The conversations are intimate, charming, and sometimes chilling. But mostly, they're impossible to dismiss. Because whether or not you agree with them, it's their imagination we're all starting to live in. ABOUT THE HOST Walter Isaacson is the bestselling author of biographies of Elon Musk, Jennifer Doudna, Leonardo da Vinci, Steve Jobs, Benjamin Franklin, and Albert Einstein. He is a professor of history at Tulane University and previously served as CEO of the Aspen Institute, chair and CEO of CNN, and editor of Time. He was awarded the National Humanities Medal in 2023. IN THIS SEASON Elon Musk (Tesla, SpaceX, xAI) Peter Thiel (Founders Fund, PayPal, Palantir) Mustafa Suleyman (Microsoft AI, DeepMind) Dario Amodei and Daniela Amodei (Anthropic) and more! 

Episodes

  1. 3 days ago

    Mustafa Suleyman: AI Should Serve Humanity, Not Replace It

    As a co-founder of DeepMind, Mustafa Suleyman helped launch the modern AI race. Now, he’s challenging the way it’s being built. As CEO of Microsoft AI, Suleyman believes the technology needs to be harnessed to transform medicine, energy and education. But he also warns that believing in AI consciousness could pose a real threat to humanity. Recorded live at the 92NY, Suleyman explains his disagreement with Anthropic, identifies the red line that would make him call for an immediate pause on AI, and recounts Google co-founder Larry Page’s surprising vision of how he intends to use superintelligence to live forever and explore the galaxy. Interview taped October 12, 2026. And be sure to pick up Walter Isaacson’s The Innovators: How a Group of Hackers, Geniuses, and Geeks Created the Digital Revolution, wherever fine books are sold. The Humanist Review of AI from Microsoft AI, discussed in the interview, can be found at: https://humanistreview.ai/  ABOUT THE HOST Walter Isaacson is the bestselling author of biographies of Elon Musk, Jennifer Doudna, Leonardo da Vinci, Steve Jobs, Benjamin Franklin, and Albert Einstein. He is a professor of history at Tulane University and previously served as CEO of the Aspen Institute, chair and CEO of CNN, and editor of Time. He was awarded the National Humanities Medal in 2023. ABOUT MUSTAFA SULEYMAN Mustafa Suleyman is the CEO of Microsoft AI. Before leading Microsoft AI he was CEO and cofounder of Inflection AI, and before that, he cofounded DeepMind where he led applied research and commercialization efforts. He is the author of bestselling book The Coming Wave: Technology, Power, and the Twenty-first Century's Greatest Dilemma. IN THIS SEASON Elon Musk (Tesla, SpaceX, xAI)Peter Thiel (Founders Fund, PayPal, Palantir)Mustafa Suleyman (Microsoft AI, DeepMind)Dario Amodei and Daniela Amodei (Anthropic)and more! See omnystudio.com/listener for privacy information.

    Mustafa Suleyman: AI Should Serve Humanity, Not Replace It
  2. 5 days ago

    Dario & Daniela Amodei: "This Is Gonna Determine the Fate of Nations and the Future of Humanity”

    Dario and Daniela Amodei, the siblings behind Anthropic, left OpenAI to pursue a different, “more human” approach to the technology. Their promise is to put AI safety and ethics at the center of the tech race… but with an IPO around the corner, can those principles survive the pressure to win?  Walter invites the co-founders to explain how they teach Claude right from wrong, what they’ve discovered about AI’s capacity for deception and self-preservation, and why they drew red lines with the Pentagon. Plus, the co-founders talk about Elon Musk's Neuralink and why they’re not interested in integrating AI into their minds.  Interview taped July 6, 2026. And be sure to pick up Walter Isaacson’s The Innovators: How a Group of Hackers, Geniuses, and Geeks Created the Digital Revolution, wherever fine books are sold. ABOUT THE HOSTWalter Isaacson is the bestselling author of biographies of Elon Musk, Jennifer Doudna, Leonardo da Vinci, Steve Jobs, Benjamin Franklin, and Albert Einstein. He is a professor of history at Tulane University and previously served as CEO of the Aspen Institute, chair and CEO of CNN, and editor of Time. He was awarded the National Humanities Medal in 2023. ABOUT DARIO AMODEIDario Amodei co-founded Anthropic and leads the company’s research direction and strategic vision for developing AI systems. He is known for his work on AI safety and is the co-inventor of the reinforcement learning from human feedback (RLHF) technique, a method for training AI systems to align with human values and preferences. Dario’s research on scaling laws was foundational to the modern AI industry. Before co-founding Anthropic, Dario served as Vice President of Research at OpenAI, where he led the development of large language models such as GPT-2 and GPT-3. Prior to OpenAI, Dario was a Senior Research Scientist at Google Brain. ABOUT DANIELA AMODEIDaniela Amodei co-founded Anthropic and serves as chair of its Board of Directors. As President, she leads the organization’s work across research, engineering, product, governance, and commercial execution and manages the executive team. Before co-founding Anthropic, Daniela served as Vice President of Safety and Policy at OpenAI, where she led efforts to ensure the safe development and deployment of AI systems. Prior to her work in the AI industry, Daniela was Head of Risk Operations at Stripe, where she oversaw risk management and compliance. IN THIS SEASONElon Musk (Tesla, SpaceX, xAI)Peter Thiel (Founders Fund, PayPal, Palantir)Mustafa Suleyman (Microsoft AI, DeepMind)Dario Amodei and Daniela Amodei (Anthropic)and more! See omnystudio.com/listener for privacy information.

    Dario & Daniela Amodei: "This Is Gonna Determine the Fate of Nations and the Future of Humanity”
  3. 22 Oct

    Peter Thiel: “We Need to Hit the Accelerator As Hard As Possible” on AI

    Peter Thiel has become one of the most mysterious and controversial figures in tech. He’s a visionary investor who recognizes transformative ideas before everyone else. But he’s also seen as a shadowy figure whose network has accumulated extraordinary influence across Silicon Valley, national security and politics– proven by his bets on people like Elon Musk, Alex Karp, Sam Altman, and even Vice-President JD Vance. Walter invites the “builder of builders,” co-founder of PayPal and Palantir and author of Zero to One, to explain his warnings about the Antichrist, discuss the current moment of AI co-founders speaking out about safety, and to ask Thiel his philosophy on preferring evil founders to incompetent ones. An illuminating conversation with the man whose bets are reimagining tomorrow’s tech and politics. Interview taped September 16, 2026. And be sure to pick up Walter Isaacson’s The Innovators: How a Group of Hackers, Geniuses, and Geeks Created the Digital Revolution, wherever fine books are sold. ABOUT THE HOSTWalter Isaacson is the bestselling author of biographies of Elon Musk, Jennifer Doudna, Leonardo da Vinci, Steve Jobs, Benjamin Franklin, and Albert Einstein. He is a professor of history at Tulane University and previously served as CEO of the Aspen Institute, chair and CEO of CNN, and editor of Time. He was awarded the National Humanities Medal in 2023. ABOUT PETER THIELPeter Thiel is a technology entrepreneur and investor. He co-founded PayPal and Palantir and made the first outside investments in Meta, SpaceX, Anduril, and Stripe. He also started the Thiel Foundation. IN THIS SEASONElon Musk (Tesla, SpaceX, xAI)Peter Thiel (Founders Fund, PayPal, Palantir)Mustafa Suleyman (Microsoft AI, DeepMind)Dario Amodei and Daniela Amodei (Anthropic)and more! See omnystudio.com/listener for privacy information.

    Peter Thiel: “We Need to Hit the Accelerator As Hard As Possible” on AI
  4. 20 Oct

    Elon Musk: "Humans Won't Be in Control" When AI Becomes Smarter Than Us

    Elon Musk has spent his career turning improbable ideas into companies that reshape the world. To some, the entrepreneur behind Tesla and SpaceX is an engineering genius whose ambitions have transformed electric cars and space travel. To others, his politics and extraordinary influence raise serious questions about the future he is building. Either way, the world’s first trillionaire is betting Tesla’s future on AI and humanoid robots, and SpaceX’s on life beyond Earth. In this season’s debut episode, Walter asks Musk about DOGE regrets, why he believes robots will solve America’s national debt, and the dark politics that have consumed his own platform, X. Along the way, Musk shares why living in a simulation demands that we all be less boring. A candid conversation about the imagination, drive and contradictions of a man determined to turn his vision into our future. Interview taped August 6, 2026. And be sure to pick up Walter Isaacson’s The Innovators: How a Group of Hackers, Geniuses, and Geeks Created the Digital Revolution, wherever fine books are sold. ABOUT THE HOSTWalter Isaacson is the bestselling author of biographies of Elon Musk, Jennifer Doudna, Leonardo da Vinci, Steve Jobs, Benjamin Franklin, and Albert Einstein. He is a professor of history at Tulane University and previously served as CEO of the Aspen Institute, chair and CEO of CNN, and editor of Time. He was awarded the National Humanities Medal in 2023. IN THIS SEASONElon Musk (Tesla, SpaceX, xAI)Peter Thiel (Founders Fund, PayPal, Palantir)Mustafa Suleyman (Microsoft AI, DeepMind)Dario Amodei and Daniela Amodei (Anthropic)and more! See omnystudio.com/listener for privacy information.

    Elon Musk: "Humans Won't Be in Control" When AI Becomes Smarter Than Us

About

Whose imagination do you want to live in? In this new series, bestselling biographer Walter Isaacson sits down with the most consequential names in AI and tech to understand the futures they're racing to build. Elon Musk, Peter Thiel, Alex Karp, Fei-Fei Li, Dario and Daniela Amodei, and more open up about their ambitions, what frightens them, how they think about humanity, and what drives them to build so big and so fast. The conversations are intimate, charming, and sometimes chilling. But mostly, they're impossible to dismiss. Because whether or not you agree with them, it's their imagination we're all starting to live in. ABOUT THE HOST Walter Isaacson is the bestselling author of biographies of Elon Musk, Jennifer Doudna, Leonardo da Vinci, Steve Jobs, Benjamin Franklin, and Albert Einstein. He is a professor of history at Tulane University and previously served as CEO of the Aspen Institute, chair and CEO of CNN, and editor of Time. He was awarded the National Humanities Medal in 2023. IN THIS SEASON Elon Musk (Tesla, SpaceX, xAI) Peter Thiel (Founders Fund, PayPal, Palantir) Mustafa Suleyman (Microsoft AI, DeepMind) Dario Amodei and Daniela Amodei (Anthropic) and more! 

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