Somatostatin receptor 5
(Redirected from SSTR5)
Somatostatin receptor type 5 is a protein that in humans is encoded by the SSTR5 gene.[5]
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR5 is a member of the superfamily of receptors having seven transmembrane segments.[6]
Ligands
[edit]- Agonists
See also
[edit]References
[edit]- 1 2 3 GRCh38: Ensembl release 89: ENSG00000162009 – Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000050824 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Takeda J, Fernald AA, Yamagata K, Le Beau MM, Bell GI (August 1995). "Localization of human somatostatin receptor 5 gene (SSTR5) to chromosome band 16p13.3 by fluorescence in situ hybridization". Genomics. 26 (3): 638–639. doi:10.1016/0888-7543(95)80195-R. PMID 7607700.
- ↑ "Entrez Gene: SSTR5 somatostatin receptor 5".
- ↑ Zhang Y, Wu N, Li Q, Hu X, Wang L, Sun JG, et al. (March 2021). "Neuroprotective effect of the somatostatin receptor 5 agonist L-817,818 on retinal ganglion cells in experimental glaucoma". Experimental Eye Research. 204 108449. doi:10.1016/j.exer.2021.108449. PMID 33465395.
- ↑ WO 2022177988, Ferrara-Cook CU, Krasner AS, "Ferrara-Cook C, Krasner AS. Somatostatin receptor type 5 agonist for the treatment of hyperinsulinism. WO 2022/177988", published 2022-02-16, assigned to Crinetics Pharmaceuticals Inc [Us] and Crinetics Pharmaceuticals, Inc.
Further reading
[edit]- Yamada Y, Post SR, Wang K, Tager HS, Bell GI, Seino S (January 1992). "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney". Proceedings of the National Academy of Sciences of the United States of America. 89 (1): 251–255. Bibcode:1992PNAS...89..251Y. doi:10.1073/pnas.89.1.251. PMC 48214. PMID 1346068.
- Montminy MR, Goodman RH, Horovitch SJ, Habener JF (1984). "Primary structure of the gene encoding rat preprosomatostatin". Proceedings of the National Academy of Sciences of the United States of America. 81 (11): 3337–3340. Bibcode:1984PNAS...81.3337M. doi:10.1073/pnas.81.11.3337. PMC 345502. PMID 6145156.
- Panetta R, Greenwood MT, Warszynska A, Demchyshyn LL, Day R, Niznik HB, et al. (March 1994). "Molecular cloning, functional characterization, and chromosomal localization of a human somatostatin receptor (somatostatin receptor type 5) with preferential affinity for somatostatin-28". Molecular Pharmacology. 45 (3): 417–427. PMID 7908405.
- O'Carroll AM, Raynor K, Lolait SJ, Reisine T (1994). "Characterization of cloned human somatostatin receptor SSTR5". Molecular Pharmacology. 46 (2): 291–298. PMID 8078491.
- Yamada Y, Kagimoto S, Kubota A, Yasuda K, Masuda K, Someya Y, et al. (September 1993). "Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype". Biochemical and Biophysical Research Communications. 195 (2): 844–852. doi:10.1006/bbrc.1993.2122. PMID 8373420.
- Yamada Y, Stoffel M, Espinosa R, Xiang KS, Seino M, Seino S, et al. (February 1993). "Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms". Genomics. 15 (2): 449–452. doi:10.1006/geno.1993.1088. PMID 8449518.
- Fukusumi S, Kitada C, Takekawa S, Kizawa H, Sakamoto J, Miyamoto M, et al. (March 1997). "Identification and characterization of a novel human cortistatin-like peptide". Biochemical and Biophysical Research Communications. 232 (1): 157–163. doi:10.1006/bbrc.1997.6252. PMID 9125122.
- Ain KB, Taylor KD, Tofiq S, Venkataraman G (1997). "Somatostatin receptor subtype expression in human thyroid and thyroid carcinoma cell lines". The Journal of Clinical Endocrinology and Metabolism. 82 (6): 1857–1862. doi:10.1210/jcem.82.6.4013. PMID 9177396. S2CID 25337792.
- de Lecea L, Ruiz-Lozano P, Danielson PE, Peelle-Kirley J, Foye PE, Frankel WN, et al. (June 1997). "Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin". Genomics. 42 (3): 499–506. doi:10.1006/geno.1997.4763. PMID 9205124.
- Jaïs P, Terris B, Ruszniewski P, LeRomancer M, Reyl-Desmars F, Vissuzaine C, et al. (August 1997). "Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours". European Journal of Clinical Investigation. 27 (8): 639–644. doi:10.1046/j.1365-2362.1997.1740719.x. PMID 9279525. S2CID 23503397.
- Hukovic N, Panetta R, Kumar U, Rocheville M, Patel YC (August 1998). "The cytoplasmic tail of the human somatostatin receptor type 5 is crucial for interaction with adenylyl cyclase and in mediating desensitization and internalization". The Journal of Biological Chemistry. 273 (33): 21416–21422. doi:10.1074/jbc.273.33.21416. PMID 9694905.
- Sharma K, Patel YC, Srikant CB (1999). "C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest". Molecular Endocrinology. 13 (1). Baltimore, Md.: 82–90. doi:10.1210/mend.13.1.0220. PMID 9892014.
- Kumar U, Sasi R, Suresh S, Patel A, Thangaraju M, Metrakos P, et al. (January 1999). "Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis". Diabetes. 48 (1): 77–85. doi:10.2337/diabetes.48.1.77. PMID 9892225.
- Rocheville M, Lange DC, Kumar U, Sasi R, Patel RC, Patel YC (March 2000). "Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers". The Journal of Biological Chemistry. 275 (11): 7862–7869. doi:10.1074/jbc.275.11.7862. PMID 10713101.
- Rocheville M, Lange DC, Kumar U, Patel SC, Patel RC, Patel YC (April 2000). "Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity". Science. 288 (5463). New York, N.Y.: 154–157. Bibcode:2000Sci...288..154R. doi:10.1126/science.288.5463.154. PMID 10753124.
- Daniels RJ, Peden JF, Lloyd C, Horsley SW, Clark K, Tufarelli C, et al. (February 2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Human Molecular Genetics. 10 (4): 339–352. doi:10.1093/hmg/10.4.339. PMID 11157797.
- Ballarè E, Persani L, Lania AG, Filopanti M, Giammona E, Corbetta S, et al. (August 2001). "Mutation of somatostatin receptor type 5 in an acromegalic patient resistant to somatostatin analog treatment". The Journal of Clinical Endocrinology and Metabolism. 86 (8): 3809–3814. doi:10.1210/jcem.86.8.7787. PMID 11502816. S2CID 17616592.
- Pasquali D, Notaro A, Esposito D, Vassallo P, Bonavolontà G, Bellastella A, et al. (September 2001). "[Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy]". Minerva Endocrinologica. 26 (3): 175–179. PMID 11753241.
- Papotti M, Bongiovanni M, Volante M, Allìa E, Landolfi S, Helboe L, et al. (May 2002). "Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis". Virchows Archiv. 440 (5): 461–475. doi:10.1007/s00428-002-0609-x. PMID 12021920. S2CID 28584328.
External links
[edit]- "Somatostatin Receptors: sst5". The International Union of Basic and Clinical Pharmacology, The British Pharmacological Society, The University of Edinburgh. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-09.
- somatostatin+receptor+5 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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